The E-Cigarette dilemma: Balancing risks and benefits for health

The Dengue Vaccine Dilemma: Balancing the Individual and Population Risks and Benefits

In a Perspective, Jacqueline Deeen discusses challenges in balancing the individual and population risks and benefits for CYD-TDV (Dengvaxia), the first available dengue vaccine.

CT Scans: Balancing Health Risks and Medical Benefits

Balancing risks and benefits of oral contraception.

We publish in this issue an authoritative and timely opinion on the effects of third-generation oral contraceptives on the incidence of venous thromboembolism (VTE) and acute myocardial infarction (AMI) among users (Spitzer, 1997). The author is a highly experienced and leading epidemiologist in the field, and his conclusions are disturbing. He details what seems to be serious misinterpretation...

Balancing the gastrointestinal benefits and risks of nonselective NSAIDs

Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used classes of medications to treat pain and inflammation. However, gastrointestinal complications associated with NSAIDs are prevalent, largely due to the frequent use of these agents. Adverse events associated with NSAIDs include minor side effects, such as dyspepsia, as well as serious complications, such a...

Balancing the risks and benefits of dual platelet inhibition.

Cardiovascular and cerebrovascular events commonly arise from atherosclerotic plaque rupture that produces platelet activation, thrombus formation, and reduction of blood flow to the brain or heart. The inhibition of platelets with aspirin is effective in the secondary prevention of acute coronary events.1 The addition of clopidogrel (i.e., dual antiplatelet therapy), a platelet P2Y12receptor a...